The effect of in vitro ã-irradiation on mitogenic responsiveness of murine lymphocytes
J. physiol. biochem
; 64(3): 179-188, jul.-sept. 2008. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-61822
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The objective of this study was to analyze the proliferative response of BALB/cmice lymphocytes after in vitro irradiation (0.05 to 6 Gy). The capability of irradiatedlymphocytes for proliferating without any stimulation and after activation withspecific T and B cell mitogens has been evaluated. The results show that ionizingradiation significantly inhibits spontaneous cellular proliferation and that induced bymitogens and that variations in the degree of inhibition are found depending on theinducing proliferation mitogens and the dosage applied. The conclusion drawn is thatdifferent lymphocyte populations have different radiosensitivities, being B cells moresensitive to ionizing irradiation than T cells. Besides, the effects of gamma-irradiationvary according to the different subpopulations of T cells or, alternatively, to differentT-dependent activation mechanisms (AU)
RESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Fito-Hemaglutininas
/
Tolerância a Radiação
/
Lipopolissacarídeos
/
Subpopulações de Linfócitos B
/
Subpopulações de Linfócitos T
/
Concanavalina A
/
Proliferação de Células
/
Relação Dose-Resposta Imunológica
/
Mitógenos
Limite:
Animais
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2008
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital La Fe/Spain