Pulse Intravenous Clomipramine as an alternative antidepressant treatment to ECT. A pilot study
Eur. j. psychiatry
; 21(4): 263-267, oct.-dic. 2007. ilus
Article
em En
| IBECS
| ID: ibc-65140
Biblioteca responsável:
ES15.1
Localização: ES15.1 - BNCS
RESUMEN
No disponible
ABSTRACT
Background and Objectives:
The aim of the study was to examine the antidepressant effect of a single pulse dose of intravenous clomipramine (200 mg i.v.) followed by oral administration as an alternative method to electroconvulsive therapy.Methods:
Twenty-one inpatients (8 male, 13 female) with major depression were included. Depression severity was measured by Montgomery Asberg Rating Scale (MADRS) and Clinical Global Impression severity scale (CGI-S) before the pulse dose and 1 week after. The day after the pulse dose, the patient was medicated with 75 mg of oral clomipramine and from day two with 150 mg clomipramine daily.Results:
The MADRS score dropped with 39% ± 22% and the CGI score with 28% ± 19% in one week. The improvement of the MADRS score after one week was 13.1(C.I.9.5-17.0). CGI-ratings dropped from a mean of 5.5 (SD 1.2) to 3.9 (SD 1.1), an improvement of 28% ± 19%.(C.I. 1.0-2.1). Both improvements were significant (p<000.1).Conclusions:
Single pulse dose clomipramine administration ameliorates depressive symptoms, and may be an alternative to ECT (AU)
Texto completo:
1
Coleções:
06-national
/
ES
Base de dados:
IBECS
Assunto principal:
Clomipramina
/
Transtorno Depressivo Maior
/
Eletroconvulsoterapia
Limite:
Humans
Idioma:
En
Revista:
Eur. j. psychiatry
Ano de publicação:
2007
Tipo de documento:
Article