Surgical management of hereditary colorectal cancer: surgery based on molecular analysis and family history
Rev. esp. enferm. dig
; 101(8): 536-540, ago. 2009. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-74449
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The importance of colorectal cancer (CRC) is increasing. Aproportion show a hereditary component, as in Lynch syndromeand Familial Adenomatous Polyposis, and a recently defined entityas well, namely, Familial Colorectal Cancer type X. The highprobability to develop CRC in these groups may, at the time ofrecognition, change surgical management, including its timing oreven the surgical technique. In some cases prophylactic surgerycan play an important role. The possibility of using tools that allowrecognition of the aforementioned syndromes, including microsatelliteinstability, immunohistochemistry for DNA mismatchrepair system proteins, and especially their mutations, is on thebasis of therapeutic strategies that differ from those employed insporadic CRC cases(AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias Retais
/
Anastomose Cirúrgica
/
Biomarcadores
/
Neoplasias Colorretais Hereditárias sem Polipose
/
Colectomia
/
Neoplasias do Colo
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. esp. enferm. dig
Ano de publicação:
2009
Tipo de documento:
Artigo
Instituição/País de afiliação:
Spanish National Cancer Research Center/Spain
/
12 de Octubre University Hospital/Spain