Design and in vitro evaluation of chlorpheniramine maleate from different eudragit based matrix patches: Effect of platicizer and chemical enhancers
Ars pharm
; 50(4): 177-194, oct.-dic. 2009. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-81360
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The release and permeation studies were carried out for developing transdermal therapeutic systems with chlorpheniramine maleate (CPM). The patches were prepared with eudragit RS-100 and RL-100 with/without polyvinyl pyrrolidone (PVP) and dibutyl phthalate (DBP) in different compositions. Thickness, tensile strength, drug content, moisture content and water absorption studies of the patches were measured. In vitro release/permeation of CPM was studied in modified Keshary-Chien diffusion cell. Chemical enhancers like l-menthol, oleic acid and phospholipon80 were added to compare the release pattern of the drug. The percent release of the drug from matrix patch increased with increase of PVP & DBP but the tensile strength decreased with the increase of DBP & PVP. Experimental release/permeation data of different formulations of the matrix systems are reported. Also the drug-polymer interaction was investigated by ATR-FTIR studies. The discussion was correlated the efficient matrix dispersion patch from suitable eudragit polymers for transdermal antihistamine applications in film device industry(AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Clorfeniramina
/
Antagonistas dos Receptores Histamínicos H1
Idioma:
Inglês
Revista:
Ars pharm
Ano de publicação:
2009
Tipo de documento:
Artigo
Instituição/País de afiliação:
Institute of Pharmacy/India
/
Jadavpur University/India