El neuron-derived orphan receptor-1 previene la apoptosis inducida por la hipoxia en las celulas endoteliales vasculares / NOR-1 prevents vascular endothelial cell apoptosis induced by hypoxia

ABSTRACT

Background NOR-1 is a nuclear receptor that is over expressed in human atherosclerotic plaques. This receptor is involved in endothelial cell (EC) growth induced by vascular endothelial growth factor (VEGF) and other mitogens. Our aim was to analyze NOR-1 regulation by hypoxia in EC. Results Hypoxia increased NOR-1 mRNA levels in a time- and dose-dependent manner. Hypoxia-induced NOR-1 expression was prevented by BAPTA-AM (a calcium chelator) but not by inhibitors of p38 MAPK, MEK1/2 (..) (AU)

RESUMEN

Antecedentes El neuron-derived orphan receptor-1 (NOR-1) es un receptor nuclear que esta sobreexpresado en las lesiones ateroscleraticas humanas y que participa en la proliferacion de las celulas endoteliales (CE) en respuesta al factor de crecimiento del endotelial vascular (VEGF) y a otros (..) (AU)