Development of a Single Combined Microencapsulated Formulation of Allopurinol and Nimesulide and Investigation of Their Release Behaviours
Ars pharm
; 51(2): 105-115, abr.-jun. 2010. ilus, tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-88751
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The aim of this study was to develop a single combined once-daily sustained releasemicroencapsulated dosage form of Allopurinol and Nimesulide using Ethyl cellulose as releasecontrolling factor and to evaluate drug release parameters as per various release kinetic models. Inorder to achieve required sustained release profile, microparticles were prepared using coacervationthermal change technique. The formulated microparticles were also characterized by physical andchemical parameters and results were found in acceptable limits. Different dissolution models wereapplied to drug release data in order to evaluate release mechanisms and kinetics. The drug releasedata fit well to the Higuchi expression. Drug release mechanism was found as a complex anomalousone(AU)
Buscar no Google
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Pesquisa
/
Análise Espectral
/
Alopurinol
/
Composição de Medicamentos
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Ars pharm
Ano de publicação:
2010
Tipo de documento:
Artigo
Instituição/País de afiliação:
COMSATS Institute of Information Technology Abbottabad/Pakistan
/
University of Bahawalpur/Pakistan