Microbiological effects of an antiseptic mouthrinsein irradiated cancer patients

ABSTRACT

Objective: To assess the microbiological effects of an antiseptic, non-alcohol based mouth-rinse containing chlorhexidineand cetylpyridinium chloride, in patients undergoing radiation therapy for head-and-neck cancer.Study Design: This was a parallel, double-blind, prospective, randomized clinical trial, including patients irradiatedas part of the therapy of head-and-neck cancer, aged 18-75, with at least 10 teeth, and willing to sign an informed consent. Cancer patients were randomly assigned to one of the two treatments (test mouth-rinse or a placebo).Three visits were scheduled (baseline, 14 and 28 days). Microbiological findings were evaluated in tongue,mucosa and subgingival samples, by means of culture. Microbiological variables were assessed by means of theMann-Whitney, Wilcoxon and chi-square tests.Results: 70 patients were screened and 36 were included. The detection of Candida species in mucosa and tonguesamples showed significant reductions in the test group. Total bacterial counts decreased in both groups frombaseline to the 2-week visit, while minor changes occurred between 2 and 4 weeks (effects on P. gingivalis, P.intermedia, C. rectus, E. corrodens).Conclusions: Within the limitations of the small sample size, this study suggests that the use of the tested mouthrinsemay lead to improvements in microbiological parameters in patients irradiated for head-and-neck cancer (AU)