Involvement of the vagus nerve and hepatic gene expression in serum adiponectin concentrations in mice
J. physiol. biochem
; 80(1): 99-112, Feb. 2024. graf
Artigo
em Inglês
| IBECS
| ID: ibc-EMG-569
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Several humoral factors, such as adiponectin and urate, have been suggested to affect metabolic syndromes. Previously, we reported a reduction in blood adiponectin concentrations after a high-fructose diet partially via the vagus nerve in rats. Although a lithogenic diet (LD), i.e., supplementation of a normal control diet (CT) with 0.6% cholesterol and 0.2% sodium cholate, reduced blood adiponectin concentrations, the involvement of the vagus nerve in this mechanism remains unclear. To estimate the involvement of the vagus nerve in the regulation of blood adiponectin concentrations using an LD, male imprinting control region mice that had been vagotomized (HVx) or only laparotomized (Sham) were administered a CT or an LD for 10 weeks. Serum adiponectin concentrations in the Sham-LD, HVx-CT, and HVx-LD groups were reduced by half compared with the Sham-CT group. The hepatic mRNA levels of fibroblast growth factor 21 (Fgf21), which reportedly stimulates adiponectin secretion from white adipose tissue, were lower in the LD groups compared with the CT groups. HepG2 hepatoma cells showed that various bile acids reduced the mRNA expression of FGF21. Moreover, the LD increased serum urate concentrations and reduced hepatic expressions of the acyl-CoA oxidase 1 (Acox1) mRNA and glucokinase, suggesting insufficient regeneration of ATP from AMP. In conclusion, serum adiponectin concentration may be regulated via the vagus nerve in normal mice, whereas a reduction of hepatic Fgf21 mRNA by bile acids may also lower serum adiponectin levels. Moreover, the LD may promote hepatic AMP accumulation and subsequently increase the serum urate concentration in mice. (AU)
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Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
ODS3 - 3A Fortalecer a implementação da estrutura da Convenção da OMS para o Controle do Tabaco
/
Agenda de Saúde Sustentável para as Américas
/
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Proteção contra Exposição
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Objetivo 9: Redução de doenças não transmissíveis
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Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
Base de dados:
IBECS
Assunto principal:
Ácido Úrico
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Nervo Vago
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Ácidos e Sais Biliares
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Infecções por Coronavirus
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Peptídeos e Proteínas de Sinalização Intercelular
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Adiponectina
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Pandemias
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Pâncreas
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Pneumonectomia
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Enfisema Pulmonar
Tipo de estudo:
Ensaio clínico controlado
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Estudo diagnóstico
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Estudo observacional
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Estudo de prevalência
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Estudo prognóstico
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Fatores de risco
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Estudo de rastreamento
Aspecto:
Determinantes sociais da saúde
Limite:
Humanos
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Adolescente
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Animais
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Criança
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Criança, pré-escolar
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Lactente
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Recém-Nascido
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Adulto
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Idoso
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Feminino
País/Região como assunto:
Europa
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México
Idioma:
Inglês
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Espanhol
Revista:
Arch. bronconeumol. (Ed. impr.)
/
J. physiol. biochem
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An. pediatr. (2003. Ed. impr.)
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Nutr. hosp
Ano de publicação:
2023
/
2022
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2024
Tipo de documento:
Artigo
Instituição/País de afiliação:
National Agriculture and Food Research Organization/Japan
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Obihiro University of Agriculture and Veterinary Medicine/Japan
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Universidad Autónoma de Nuevo León/México
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Hospital General de México Dr. Eduardo Liceaga/México
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Hospital Universitario La Paz/España
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Hospital Universitario Ramón y Cajal/España
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Hospital Universitario de Fuenlabrada/España
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Hospital Universitario de Getafe/España
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Hospital Universitario y Politécnico La Fe/Spain
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Puerta del Hierro University Hospital of Madrid/Spain