Identification of immune-related signature with prognosis in children with stage 4 and 4S neuroblastoma / Identificación de firma relacionada con el sistema inmunológico con pronóstico en niños con neuroblastoma en estadio 4 y 4S
Clin. transl. oncol. (Print)
; 26(4): 905-916, Abr. 2024. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-VR-53
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Objective:
Spontaneous regression of tumors is an attractive phenomenon that most commonly occurs in stage 4S neuroblastoma (NB). However, the mechanism underlying this phenomenon remains unclear.Methods:
Datasets correlated with NB were downloaded from online public databases, the differentially expressed genes (DEGs) between stage 4 and 4S associated with immunity were identified, and functional enrichment analysis was utilized to explore the potential functions and signaling pathways of these DEGs. In addition, based on these DEGs, a prognostic signature was constructed and validated, and differences in immune cell infiltration were analyzed.Results:
A total of 13 DEGs were finally identified, and functional enrichment analysis revealed that these DEGs were primarily enriched in the positive regulation of neuron differentiation and TGF-β signaling pathway. The signature successfully stratifies patients into two risk score groups and performs well in judging prognosis and predicting overall survival time. In addition, the prognostic value of the risk score calculated by the signature was independent of clinical factors. The results of immune cell infiltration showed that patients with a high infiltration of resting CD4 + memory T cells had a better prognosis, while plasma cells had a worse prognosis.Conclusion:
The results of the functional enrichment analysis of these identified DEGs suggested that these DEGs may be related to spontaneous regression of NB. In addition, the prognostic signature has the potential to create new risk stratification in patients with NB.(AU)
Buscar no Google
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
ODS3 - Meta 3C Aumentar o financiamento da saúde e o recrutamento, desenvolvimento, formação e retenção da força de trabalho da saúde
/
Agenda de Saúde Sustentável para as Américas
/
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
/
ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Problema de saúde:
Autoridade e Responsabilidade dos Profissionais de Saúde
/
Objetivo 3: Recursos humanos em saúde
/
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Doenças Negligenciadas
/
Zoonoses
/
COVID-19
Base de dados:
IBECS
Assunto principal:
Infecções por Coronavirus
/
Educação Médica
/
Pandemias
/
Pacientes
/
Prognóstico
/
Psicoterapia
/
Qualidade da Assistência à Saúde
/
Doses de Radiação
/
Remissão Espontânea
/
Reumatologia
Tipo de estudo:
Estudo de etiologia
/
Guia de prática clínica
/
Estudo observacional
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Humanos
/
Feminino
/
Masculino
/
Criança
/
Idoso
/
Criança, pré-escolar
País/Região como assunto:
Europa
/
Ásia
Idioma:
Espanhol
/
Inglês
Revista:
An. pediatr. (2003. Ed. impr.)
/
Cir. pediátr
/
Clin. transl. oncol. (Print)
/
Enferm. intensiva (Ed. impr.)
/
Gac. sanit. (Barc., Ed. impr.)
/
Int. microbiol
/
Nutr. clín. diet. hosp
/
Radiología (Madr., Ed. impr.)
/
Reumatol. clín. (Barc.)
/
Rev. Fund. Educ. Méd. (Ed. impr.)
Ano de publicação:
2022
/
2023
/
2024
/
2021
Tipo de documento:
Artigo
Instituição/País de afiliação:
, Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich/Argentina
/
Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional (CIIDIR)/México
/
Chengdu Agricultural College/China
/
Childrens Hospital/Peoples Republic of China
/
Consejo General de ColegiosOficiales de Médicos/España
/
Fundació Institut Universitari per a la recerca a lAtenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol)/España
/
Hospital Bernardino Rivadavia/Argentina
/
Hospital Clinic of Barcelona/España
/
Hospital Clinic/España
/
Hospital Clínico San Carlos/España