Evaluation of acellular DPT vaccines in infants
Mem. Inst. Butantan
; 53(1,supl): 21-9, 1991. ilus
Artigo
em Inglês
| LILACS, Sec. Est. Saúde SP
| ID: lil-100255
Biblioteca responsável:
BR91.2
RESUMO
Two acellular DPT vaccines containing, as pertussis components, the genetically detoxified pertussis toxin mutant PT-9K/129G, either alone or combined with FHA and 69K, were evaluated for safety and immunogenicity in infants 8-14 months old. Both vaccines induced very mild local reactions which were consistent with the presence of alum and the previous administration of two doses of whole-cell DPT vaccine. A marked increase in specific antibodies to each pertussis component and in pertussis toxin neutralizing antibodies was observed after one dose of either acellular vaccines. All vaccinees also acquired an excellent protective immunity against diphtheria and tetanus, as assessed in vitro and in vivo
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Brasil
Base de dados:
LILACS
/
Sec. Est. Saúde SP
Assunto principal:
Vacinas
Limite:
Criança
Idioma:
Inglês
Revista:
Mem. Inst. Butantan
Ano de publicação:
1991
Tipo de documento:
Artigo