Nifedipina reduce el aumento de calcio intracelular en el hiperparatiroidismo primario: rol de los canales de calcio y de PTH / Nifedipine reduces the increase of intracellular calcium in primary hyperparathyroidism: role of calcium channels and PTH

ABSTRACT

Free intracellular calcium is increased in primary hyperparathyroidism (HPT) and may related to the higher incidence of hypertension in this disease. This elevation returns to normal when primary HPT is corrected. In essential hypertension, an alteration in calcium channels allows a intracellular accumulation of calcium. Aiming to assess if a similar mechanism operates in primary HPT, we measured intracellular calcium concentrations using QUIN-2-AM, before and after a 10 mg sublingual dose of nifedipine, in 9 subjects with primary HPT, 12 subjects with essential hypertension and 17 normal controls. Intracellular calcium was higher in subjects with primary HPT and with essential hypertension than in normal controls (276 ñ 56,343 ñ 50 and 113 ñ 12 nM respectively). Among patients witj primary HPT, intracellular calcium correlated with plasma PTH (r=0.82). Nifedipine reduced intracellular calcium to 173 ñ 36 nM in subjects with primary HPT and to 188 ñ 35 nM in those with essential hypertension. In the latter, the decreased in intracellular calcium and blood pressure correlated significantly (r=0.65 p<0,03). We conclude that increased intracellular calcium in primary HPT and essential hypertension seems to depend on an increased inflow through specific channels. However in primary HPT, this alteration is related to PTH levels