A new mutant hairless mouse with limph node hyperplasia and late onset of autoimmune pathology
Braz. j. med. biol. res
; 27(10): 2401-5, Oct. 1994. ilus
Artigo
em Inglês
| LILACS
| ID: lil-152620
Biblioteca responsável:
BR1.1
ABSTRACT
Adult BALB/c male mice were injected with a single dose of ethyl nitroso urea (ENU; 250 mg/Kg, ip) and mated to C57BL/6, DBA/2 AND A/J adult females 13 weeks later. F1 males were mated with BALB/c females and F2 females were then backcrossed to the F1 parents. One BALB/c male mouse thus teated gave origin to a mutant presenting hair and skin alterations similar to those of natural hairless mutants. The new mutation is located on chromosome 14 near the Es10 locus, and probably at the same locus for the hairless mutation. Similar to the hairless mouse, this new mutant has a normal phenotype at birth and after three weeks starts to loose hair which is never replaced. Additionally, the skin becomes thickened and wrinkled. One feature that distinguishes this mutant from other hairless mice is the peculiar enlargement of its axillary and cervical lymph nodes. The new mutant develops membranoproliferative glomerulonephritis similar to the rhino mouse, one of the hariless allele mutants already described in the literature, but with a much later onset
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Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Ureia
/
Hiperplasia do Linfonodo Gigante
/
Mutação
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1994
Tipo de documento:
Artigo
/
Congresso e conferência