Effect of conbined administration of counterregulatory hormones during insulin-induced hypoglycemia in rats: lipolysis mediated by a Beta-adrenergic mechanism contributes to hyperglycemia
Braz. j. med. biol. res
; 27(12): 2883-7, Dec. 1994. graf
Artigo
em Inglês
| LILACS
| ID: lil-153288
Biblioteca responsável:
BR1.1
ABSTRACT
The synergistic effect of combined injection of glucagon (G), cortisol (C) and phenylephrine + isoproterenol (E) during hypoglycemia in male adult Wistar rats was investigated. For this purpose we injected insulin (1 mg/kg), individually or combined (G+C, G+E, C+E and C+G+E). All drugs were injected ip and all rats were killed 60 min after insulin injection. The rise in glycemia with C+G+E was greater (delta = 107 mg/dl) than the sum of the responses to injection of C, G and E individually, or in double combination plus any single hormone injection. This synergistic effect was reproduced by G + C + isoproterenol (Iso) but not by G + C + phenylephrine (delta = 0 mg/dl). The results also showed a clear relationship between hyperglycemia and lipolysis. Thus, lipolysis mediated by a ß-adrenergic mechanism played a significant role in promoting hyperglycemia when Iso was combined with G and C
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Glucagon
/
Hidrocortisona
/
Hipoglicemia
/
Insulina
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1994
Tipo de documento:
Artigo
/
Congresso e conferência