Citoquinas, factores de crecimiento y enfermedad ósea metabólica / Cytokines, growth factors and metabolic bone disease
Rev. méd. Chile
; 124(2): 248-57, feb. 1996. ilus, tab
Artigo
em Espanhol
| LILACS
| ID: lil-173328
Biblioteca responsável:
CL1.1
RESUMO
Cytokines are polypeptides that bind to membrane receptors and may act in an endocrine, paracrine or autocrine way. Several cytokines and growth factors may be produced by bone cells, stored in the matrix or act on them. Osteoclast derive from the bone marrow stem cell and, as monocytes, belong to the family of tissue macrophages. Their specific function is bone resorption. Interleukin 1, 6 and 11, transforming growth factor and tumor necrosis factor stimulate osteoclast mediated bone resorption. Interleukin 1 is the most potent bone resorption agent and seems to be identical to osteoclast activation factor, identified in multiple myeloma. The role of interleukin 1, 6 and 11 and tumor necrosis factors in postmenopausal osteoporosis triggered by the fall in estrogen levels, has not been well defined yet. Cytokines that increase bone formation are insulin like growth factors I and II, transforming growth factor, platelet derived growth factor and bone morphogenic proteins. Probably, tumor necrosis factor and interferon-ç have a depressor effect on bone formation. Cytokines and growth factors, liberated from bone cells or from the matrix during osteoclastic work, could be the signals responsible for coupling bone formation and resorption
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Osso e Ossos
/
Citocinas
/
Substâncias de Crescimento
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1996
Tipo de documento:
Artigo