Glycation of blood proteins during pregnancy and lactation in the rat
P. R. health sci. j
; 11(2): 69-71, ago. 1992.
Artigo
em Inglês
| LILACS
| ID: lil-176755
Biblioteca responsável:
BR1.1
RESUMO
Non-enzymatic glycation of blood proteins is a time and concentration dependent process and has been used clinically to monitor carbohydrate metabolism during human pregnancy. Since gestation in rats is of much shorter duration than in humans (3 weeks vs 9 mos) the question was raised whether similar differences in glycated proteins could be observed. Therefore, levels of glucose, glycated hemoglobin and fructosamine were measured during normal pregnancy and lactation in rats. Glucose levels during late pregnancy were significantly lower than in non pregnant and early pregnant rats. During lactation glucose levels return to normal. Glycated hemoglobin paralleled glucose decrease during late pregnancy and increased during lactation. Fructosamine followed a similar pattern. Therefore glycated hemoglobin and fructosamine appear to be reliable indicators of glucose status during gestation and lactation similar to humans and may have value as predictors of gestational diabetes mellitus once a suitable rat model is developed
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Lactação
/
Prenhez
/
Proteínas Sanguíneas
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Gravidez
Idioma:
Inglês
Revista:
P. R. health sci. j
Assunto da revista:
Medicina
Ano de publicação:
1992
Tipo de documento:
Artigo