Pulmonary emphysema induced by passive smoking: an experimental study in rats
Braz. j. med. biol. res
; 30(10): 1241-7, Oct. 1997. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-201545
Biblioteca responsável:
BR1.1
RESUMO
We describe a short time model for inducing experimental emphysema in rats chronic tobacco smoke inhalation. Three groups of male Wistar rats (6 months old) were studied controls (N = 8), rats intoxicated for 45 days (s-45, N = 7) or for 90 days (s-90, N = 8). The exposed animals were intoxicated 3 times a day (10 cigarettes per exposure period), 5 days a week. Pulmonary damage was assessed by means of functional tests and quantitative pathological examination of the airways and lung parenchyma. The s-45 and s-90 animals were similar in terms of functional residual capacity (FRC) corrected for body weight (FRC/kg) but both groups of smoking rats exhibited significantly higher FRC/kg values than the controls (s-45=6.33; s-90=6.46; controls=3.78;P<0.05). When the two groups of smoking rats were pooled together and compared to controls, they showed decreased lung elastance (1.6 vs 2.19; P = 0.046) and increased mean linear intercept (Lm) (85.14 vs 66.44; P = 0.025). The s-90 animals presented higher inflammation and muscular hypertrophy at the level of the axial bronchus than the controls (P<0.05). When smoking groups were pooled and compared to controls, they presented significantly higher inflammation at the lateral level (P = 0.028), as well as airway secretory hyperplasia (P = 0.024) and smooth muscle hypertrophy ( P = 0.005) at the axial level. Due to its simplicity, low cost and short duration, this technique may be a useful model to obtain new information about airspace remodeling due to chronic tobacco consumption.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - 3A Fortalecer a implementação da estrutura da Convenção da OMS para o Controle do Tabaco
/
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Proteção contra Exposição
/
Meta 3.9: Reduzir o número de mortes por produtos químicos perigosos e contaminação do ar e água do solo
Base de dados:
LILACS
Assunto principal:
Enfisema Pulmonar
/
Poluição por Fumaça de Tabaco
/
Modelos Animais de Doenças
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1997
Tipo de documento:
Artigo