Your browser doesn't support javascript.
loading
Gastric emptying in rats with acetaminophen-induced hepatitis
Braz. j. med. biol. res ; 31(9): 1133-9, sept. 1998. ilus
Artigo em Inglês | LILACS | ID: lil-222961
Biblioteca responsável: BR1.1
ABSTRACT
The objective of this work was to study the gastric emptying (GE) of liquids in fasted and sucrose-fed rats with toxic hepatitis induced by acetaminophen. The GE of three test meals (saline, glucose and mayonnaise) was evaluated in Wistar rats. For each meal, the animals were divided into two groups (N = 24 each). Group I was fed a sucrose diet throughout the experiment (66 h) while group II was fasted. Forty-two hours after the start of the experiment, each group was divided into two subgroups (N = 12 each). Subgroup A received a placebo and subgroup B was given acetaminophen (1 g/kg). Twenty-four hours later, the GE of the three test meals was assessed and blood samples were collected to measure the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and acetaminophen. In group IB, the mean AST and ALT values were 515 and 263 IU/l, respectively, while for group IIB they were 4014 and 2472 IU/l, respectively. The mean serum acetaminophen levels were higher in group IIB (120 µg/ml) than in group IB (87 µg/ml). The gastric retention values were significantly higher in group IIB than in group IIA for all three test meals saline, 51 vs 35 percent; glucose, 52 vs 38 percent and mayonnaise, 51 vs 29 percent(median values). The correlation between gastric retention and AST levels was significant (P<0.05) for group IIB for the three test meals r = 0.73, 0.67 and 0.68 for saline, glucose and mayonnaise, respectively. We conclude that GE is altered in rats with hepatic lesions induced by acetaminophen, and that these alterations may be related to the liver cell necrosis caused by the drug
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Analgésicos não Narcóticos / Doença Hepática Induzida por Substâncias e Drogas / Esvaziamento Gástrico / Acetaminofen Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 1998 Tipo de documento: Artigo
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Analgésicos não Narcóticos / Doença Hepática Induzida por Substâncias e Drogas / Esvaziamento Gástrico / Acetaminofen Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 1998 Tipo de documento: Artigo
...