Asociación entre la variación genética de MSX1 (Hox-7) y la fisura labiopalatina no sindrómica en población chilena / Association between the genetic variation of MSX1 (Hox-7) and non syndromic cleft lip palate in chilean subjects
Rev. méd. Chile
; 126(6): 637-45, jun. 1998. ilus, tab
Artigo
em Espanhol
| LILACS
| ID: lil-229005
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
Homeotic genes have regulatory functions during development. It has been postulated that the human Msx-1 homeotic gene can be involved in the etiology of non syndromic cleft lip palate, since its homologous Msx-1 is involved in cleft palate of mice.Aim:
To perform an association analysis between the genetic variation of Msx-1 and non syndromic cleft lip palate in Chilean subjects. Patients andmethods:
Seventy patients with non syndromic cleft lip palate, 136 healthy relatives of these patients and 69 non related normal individuals were studied. CA microsatellite in Msx- gene, that was amplified with PCR, was studied.Results:
No differences in the genetic frequencies of Msx-1 alleles, were observed in the three groups studied. Allelic heterogeneity for allele 2 seems to be related to cases of non syndromic cleft lip palate from multiplex families and heterogeneity for allele 3 is related with simplex families cases.Conclusions:
These results seem to support the hypothesis of genetic heterogeneity in the etiology of non syndromic cleft lip palate
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Fenda Labial
/
Fissura Palatina
/
Alelos
/
Modelos Genéticos
Tipo de estudo:
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Chile
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1998
Tipo de documento:
Artigo
/
Documento de projeto