Antipsychotic profile of alstonine: ethnopharmacology of a traditional Nigerian botanical remedy
An. acad. bras. ciênc
; 71(2): 189-201, jun. 1999. ilus, graf
Article
em En
| LILACS
| ID: lil-234513
Biblioteca responsável:
BR1.1
ABSTRACT
Although recently developed drugs have brought significant improvement, the treatment of psychotic disorders still presents serious drawbacks. Since inherent complexity and lack of satisfactory understanding of the underlying pathophysiology impose limits for rational drug design, resourceful approaches in the search for antipsychotics are pertinent. This paper reports pharmacological properties of alstonine, a heteroyohimbine type alkaloid, Which exbitited an antipsychotic-like profile, inhibiting amphetamine-induced lethaly, apomorphine-induced steotypy and potentiating barbiturate-induced slleping time. Atypical features of alstonine were the prevention of haloperidol-induced catalepsy and lack of direct interaction with D1, D2 and 5-HT2A receptors, classically linked to antipsychotic mechanism of action.
Buscar no Google
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Plantas Medicinais
/
Antipsicóticos
/
Alcaloides de Triptamina e Secologanina
Limite:
Animals
País/Região como assunto:
Africa
Idioma:
En
Revista:
An. acad. bras. ciênc
Assunto da revista:
CIENCIA
Ano de publicação:
1999
Tipo de documento:
Article
/
Congress and conference
País de publicação:
Brasil