Efecto agudo de dobutamina y amrinona sobre la hemodinamia y perfusión esplácnica de pacientes en shock séptico / Acute effect of dobutamine and amrinone on hemodynamics and splanchnic perfusion in septic shock patients
Rev. méd. Chile
; 127(6): 660-6, jun. 1999. tab
Artigo
em Espanhol
| LILACS
| ID: lil-245307
Biblioteca responsável:
CL1.1
RESUMO
Background:
Vasoactive drugs used in the reanimation of septic patients, can modify splanchnic perfusion.Aim:
To compare the effects of dobutamine and amrinone on gastric intramucosal pH (pHi), lactate levels and hemodynamics in surgical patients with compensated septic shock. Patients andmethods:
Fourteen postoperative patients with abdominal sepsis and compensated septic shock (pHi <7.32 or lactate >2.5 mmol/l) were studied in a prospective, randomized, unblinded study. Patients were randomized to receive (Group 1, n=7) dobutamine at 5 µg/Kg/min or (Group 2, n=7) amrinone at 5 µg/Kg/min. Hemodynamic data, arterial lactate and pHi were measured before and 30, 60 and 120 minutes after starting drug infusion.Results:
Both drugs were associated with a decrease in lactate levels. Dobutamine infusion, but not amrinone, increased gastric pHi, as well as cardiac index and oxygen delivery.Conclusions:
An improvement in gastric pHi associated with an increase in oxygen delivery, was observed with dobutamine. Amrinone showed no effect at the fixed, low dose used in the study
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Choque Séptico
/
Amrinona
/
Dobutamina
Tipo de estudo:
Ensaio clínico controlado
/
Estudo de etiologia
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1999
Tipo de documento:
Artigo
/
Congresso e conferência
País de afiliação:
Chile