Trypanosoma cruzi-cardiomyocytes: new contributions regarding a better understanding of this interaction
Mem. Inst. Oswaldo Cruz
; 94(suppl.1): 149-52, Sept. 1999.
Artigo
em Inglês
| LILACS
| ID: lil-245607
Biblioteca responsável:
BR1.1
ABSTRACT
The present paper summarizes new approaches regarding the progress done to the understanding of the interaction of Trypanosoma cruzi-cardiomyocytes. Mannose receptors localized at the surface of heart muscle cell are involved in binding and uptake of the parasite. One of the most striking events in the parasite-heart muscle cells interaction is the disruption of the actin cytoskeleton. We have investigated the regulation of the actin mRNA during the cytopathology induced in myocardial cells by the parasite. T. cruzi invasion increases calcium resting levels in cardiomyocytes. We have previously shown that Ca2+ ATPase of the sarcoplasmic reticulum (SERCA) is involved in the invasion of T. cruzi in cardiomyocytes. Treating the cells with thapsigargin, a drug that binds to all SERCA ATPases and causes depletion of intracellular calcium stores, we found a 75 per cent inhibition in the T. cruzi-cardiomyocytes invasion.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Trypanosoma cruzi
/
Comunicação Celular
/
Miocárdio
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
1999
Tipo de documento:
Artigo
/
Congresso e conferência
País de afiliação:
Brasil
/
Estados Unidos