Infecciones sistémicas por levaduras en un hospital general: correlación entre estudio de susceptibilidad in vitro y supervivencia de los pacientes al episodio de infección fúngica / Systemic yeast infections in a general hospital: correlation between antifungal susceptibility and patient survival
Rev. méd. Chile
; 130(6): 661-665, jun. 2002. tab
Artigo
em Espanhol
| LILACS
| ID: lil-317498
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
Fungi are important causal agents of nosocomial infections, that usually have high mortality rates.Aim:
To evaluate the species distribution and susceptibility patterns of deep yeast infections in a General Hospital and to correlate those results with patient survival. Material andmethods:
Twenty one strains (from five pediatric and 16 from adult patients) were studied. Antifungal Susceptibility Testing (AST) to Amphotericin B (Anfb), Fluorocytosine (5FC), Fluconazole (FZ) and Itraconazole (IZ) was performed according to the EUCAST document. Clinical data of patients was obtained and survival to the infection was recorded.Results:
C. albicans was isolated in 11 samples (52 percent), C. parapsilosis in three samples (14 percent), C. glabrata in two samples (9 percent), C. tropicalis in one sample (5 percent) and C. neoformans in four samples (19 percent). Twenty three percent of fungi were recovered at the Surgical Intensive Care Unit. The MICs ranged between 0.25 and 0.5 µg/mL for Anfb; between 0.25 and 16 µg/ml for SFC, between 0.12 and 32 µg/mL for FZ and 0.015 and 0.5 µg/mL for IZ. No association between antifungal susceptibility and patient survival was observed.Conclusions:
C. albicans continues to be the most frequently isolated yeast, however, non-albicans species are an emergent group causing nosocomial infections. Surgical procedures are the main source of fungal infections in this sample
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Base de dados:
LILACS
Assunto principal:
Candidíase
/
Infecção Hospitalar
/
Antifúngicos
Limite:
Adulto
/
Criança
/
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Chile
/
Espanha
Instituição/País de afiliação:
Instituto de Salud Carlos III/ES