Teste de esforço em hipertensos em uso de diferentes inibidores da enzima conversora da angiotensina / Exercise testing in hypertensive patients taking different angiotensin-converting enzyme inhibitors
Arq. bras. cardiol
; 80(2): 127-137, Feb. 2003. tab, graf
Artigo
em Português, Inglês
| LILACS
| ID: lil-329092
Biblioteca responsável:
BR1.1
RESUMO
OBJECTIVE:
To compare blood pressure response to dynamic exercise in hypertensive patients taking trandolapril or captopril.METHODS:
We carried out a prospective, randomized, blinded study with 40 patients with primary hypertension and no other associated disease. The patients were divided into 2 groups (n=20), paired by age, sex, race, and body mass index, and underwent 2 symptom-limited exercise tests on a treadmill before and after 30 days of treatment with captopril (75 to 150 mg/day) or trandolapril (2 to 4 mg/day).RESULTS:
The groups were similar prior to treatment (p<0.05), and both drugs reduced blood pressure at rest (p<0.001). During treatment, trandolapril caused a greater increase in functional capacity (+31 percent) than captopril (+17 percent; p=0.01) did, and provided better blood pressure control during exercise, observed as a reduction in the variation of systolic blood pressure/MET (trandolapril 10.7±1.9 mmHg/U vs 7.4±1.2 mmHg/U, p=0.02; captopril 9.1±1.4 mmHg/U vs 11.4±2.5 mmHg/U, p=0.35), a reduction in peak diastolic blood pressure (trandolapril 116.8±3.1 mmHg vs 108.1±2.5 mmHg, p=0.003; captopril 118.2±3.1 mmHg vs 115.8±3.3 mmHg, p=0.35), and a reduction in the interruption of the tests due to excessive elevation in blood pressure (trandolapril 50 percent vs 15 percent, p=0.009; captopril 50 percent vs 45 percent, p=0.32).CONCLUSION:
Monotherapy with trandolapril is more effective than that with captopril to control blood pressure during exercise in hypertensive patients
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Pressão Sanguínea
/
Inibidores da Enzima Conversora de Angiotensina
/
Captopril
/
Teste de Esforço
/
Hipertensão
/
Indóis
Tipo de estudo:
Ensaio clínico controlado
/
Estudo observacional
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
/
Português
Revista:
Arq. bras. cardiol
Assunto da revista:
Cardiologia
Ano de publicação:
2003
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal Fluminense/BR