Effect of the lipophilic o-naphthoquinone CG 10-248 on rat liver mitochondria structure and function
Biocell
; 26(2): 237-245, Aug. 2002.
Artigo
em Inglês
| LILACS
| ID: lil-335848
Biblioteca responsável:
BR1.1
RESUMO
CG 10-248 (3,4-dihydro-2,2 dimethyl-9-chloro-2H-naphtho[1,2b]pyran-5,6-dione), a beta-lapachone analogue, modified the ultrastructure of rat liver mitochondria in vitro, in the absence of added oxidizable substrates. The condensed mitochondrial state was replaced by the orthodox or swollen state to a significant degree. The number of modified mitochondria depended on incubation time and quinone concentration, in the 25-100 microM range. Under the same experimental conditions, mitochondrial respiration was uncoupled as indicated by the increase in the rate of succinate oxidation by controlled mitochondria in metabolic state "4" (not in state "3"), and by the activation of latent F0F1-ATP synthase. Taking into account structural similarities, the results reported here may be valid for other o-naphthoquinones, such as beta-lapachone.
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Mitocôndrias Hepáticas
/
Naftoquinonas
Limite:
Animais
Idioma:
Inglês
Revista:
Biocell
Assunto da revista:
Clulas
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Argentina
Instituição/País de afiliação:
University of Buenos Aires/AR