Homocisteína en niños y adolescentes. Relación con historia familiar de enfermedad cardiovascular / Serum homocysteine in children and adolescents. Relation with family history of cardiovascular disease
Rev. méd. Chile
; 131(9): 997-1002, sept. 2003.
Artigo
em Espanhol
| LILACS
| ID: lil-356013
Biblioteca responsável:
CL12.1
ABSTRACT
BACKGROUND:
Hyperhomocysteinemia is an independent cardiovascular risk factor that depends on folate and vitamin B12 nutrition.AIM:
To measure homocysteine, folic acid and vitamin B12 serum levels in healthy children with and without a family history of cardiovascular disease. SUBJECTS ANDMETHODS:
Forty children aged 6 to 15 years with a family history of cardiovascular disease, and 40 age and sex matched children without such history were studied. Serum homocysteine, folic acid and vitamin B12 were measured in a fasting blood sample. Homocysteine was measured by a fluorescence polarization immunoassay (FPIA), vitamin B12 by enzymatic microparticle assay, covered with intrinsic factor and folic acid by ionic capture, using commercial kits.RESULTS:
Children with family history of cardiovascular disease had higher homocysteine levels than their counterparts without family history (7.9 +/- 3 and 5.8 +/- 2 mumol/l respectively, p < 0.03), but similar folic acid (5.2 +/- 1.8 and 5.5 +/- 1.4 pg/ml respectively) and vitamin B12 levels (431 +/- 213 and 445 +/- 209 ng/ml respectively). There was a negative and significant correlation between homocysteine and folic acid and vitamin B12 levels.CONCLUSIONS:
Children with a family history of cardiovascular disease have higher levels of serum homocysteine than those without such history, despite having similar levels of folic acid and vitamin B12.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Doenças Cardiovasculares
/
Homocisteína
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Adolescente
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2003
Tipo de documento:
Artigo
País de afiliação:
Chile