Dried blood spots as a practical and inexpensive source for human immunodeficiency virus and hepatitis C virus surveillance
Mem. Inst. Oswaldo Cruz
; 100(4): 365-370, July 2005. mapas, tab
Artigo
em Inglês
| LILACS
| ID: lil-405990
Biblioteca responsável:
BR1.1
RESUMO
Passive surveillance of infectious diseases with a high percentage of asymptomatic cases or long incubation periods, such as acquired immunodeficiency syndrome (AIDS), does not reflect the current transmission dynamics. Thus, a multi-strategic surveillance, such as the human immunodeficiency virus (HIV) sentinel surveillance proposed by the World Health Organization (WHO), is necessary. The Brazilian HIV sentinel surveillance was started in May 1992 with this purpose. The objectives of this study were to evaluate the feasibility and costs of HIV and hepatitis C virus (HCV) surveillance using dried blood spots (DBS) collected for neonatal screening of metabolic diseases in the state of Minas Gerais, Brazil. This was accomplished through the comparison of HIV and HCV seroprevalence with previous Brazilian studies. From December 2001 to June 2002, 24,905 newborns were tested for HIV and 4211 for HCV. HIV seroprevalence was 0.25 percent and the 95 percent confidence interval (CI) was 0.18, 0.31 percent; and HCV seroprevalence was 0.71 percent and the 95 percent CI was 0.46, 0.97 percent. These numbers are similar to previous Brazilian studies. Cost in this study was approximately US$ 3.10 per sample, which was roughly one third of the cost of the same exam at the Brazilian HIV sentinel surveillance. We conclude that it is possible and more cost-effective to use DBS for infectious diseases surveillance, albeit it is still necessary to compare these results with the usual sentinel methodology in a concomitant trial.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Problema de saúde:
Meta 3.8 Atingir a cobertura universal de saúde
/
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Hepatite
Base de dados:
LILACS
Assunto principal:
Coleta de Amostras Sanguíneas
/
Infecções por HIV
/
Triagem Neonatal
/
Custos de Cuidados de Saúde
/
Hepatite C
/
Vigilância de Evento Sentinela
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Humanos
/
Recém-Nascido
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
1Universidade José do Rosário Vellano/BR
/
Faculdade de Medicina/BR
/
Núcleo de Pesquisa em Apoio Diagnóstico/BR
/
Universidade Federal de Minas Gerais/BR
/
Universidade José do Rosário Vellano/BR