Estudio de la actividad comparativa in vitro de telitromicina en patógenos respiratorios adquiridos en la comunidad en 13 centros clínicos chilenos / In vitro activity of telithromycin against community acquired respiratory pathogens
Rev. méd. Chile
; 133(4): 419-425, abr. 2005. ilus
Article
em Es
| LILACS
| ID: lil-417379
Biblioteca responsável:
CL12.1
ABSTRACT
Background:
Telithromycin is a new ketolide antimicrobial, that can be useful for the treatment of respiratory infections.Aim:
To compare in vitro activity of telithromycin against respiratory pathogens, isolated in outpatient clinics. Material andmethods:
Two hundred eighty strains isolated from patients with respiratory infections, were studied. The strains studied were S pneumoniae, penicillin sensitive (SPNS57); intermediate (SPNI35), resistant (SPNR25); S pyogenes (SP57); H influenzae (HIN 51); M catarrhalis (MC25) and S aureus meticillin sensitive (SAUS30). Minimal inhibitory concentration (MIC) by broth microdilution was studied for telitrhomycin and levofloxacin in all strains. Other antimicrobials studied, but not in all strains were erythromycin, clindamycin, trimetoprim sulphamethoxazole, oxacillin, amoxicillin-clavulanic acid and cefuroxime.Results:
All strains were sensible to telithromycin at a concentration ¡4 µg/ml. MIC 90 and its range for SPNS was 0.03 µg/ml (¡0.004-0.12), for SPNI was 0.03 µg/ml (¡0.004-025), for SPNR was 0.06 µg/ml (¡0.004-0.25), for HIN was 2 µg/ml (0.12-4), for SP was 0.5 µg/ml (¡0.004-2), for MC was 0.5 µg/ml (0.06-2) and for SAU was 0.25 µg/ml (0.06-0.25).Conclusions:
All studied pathogens were sensible to telithromycin in vitro. This antimicrobial is an alternative for the treatment of community acquired respiratory infections.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Infecções Respiratórias
/
Antibacterianos
Tipo de estudo:
Clinical_trials
Limite:
Humans
País/Região como assunto:
America do sul
/
Chile
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Chile