Relationship of age to outcome and clinicopathologic findings in men submitted to radical prostatectomy
Int. braz. j. urol
; 31(6): 534-540, Nov.-Dec. 2005.
Article
em En
| LILACS
| ID: lil-420479
Biblioteca responsável:
BR1.1
RESUMO
OBJECTIVE:
It is controversial whether age is associated with higher grade and worse outcome. Some studies have not found age to be related to outcome nor younger age to be associated with better response to therapy. MATERIALS ANDMETHODS:
The study population consisted of 27 patients aged 55 years or younger and 173 patients 56 years or older submitted to radical prostatectomy. The variables studied were preoperative PSA, time to PSA progression following radical prostatectomy and pathologic findings in surgical specimens Gleason score, Gleason predominant grade, positive surgical margins, tumor extent, extraprostatic extension (pT3a), and seminal vesicle invasion (pT3b).RESULTS:
Comparing patients aged 55 years or younger and 56 years or older, there was no statistically significant difference for all variables studied preoperative PSA (p = 0.4417), Gleason score (p = 0.3934), Gleason predominant grade (p = 0.2653), tumor extent (p = 0.1190), positive surgical margins (p = 0.8335), extraprostatic extension (p = 0.3447) and seminal vesicle invasion (p > 0.9999). During the study period, 44 patients (22 percent) developed PSA progression. No difference was found in the time to biochemical progression between men aged 55 years or younger and 56 years or older.CONCLUSION:
Our findings suggest that age alone do not influence the biological aggressiveness of prostate cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Neoplasias da Próstata
/
Glândulas Seminais
/
Antígeno Prostático Específico
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
Idioma:
En
Revista:
Int. braz. j. urol
Assunto da revista:
UROLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil