Espectroscopia de prótons na demência de Alzheimer e no comprometimento cognitivo / Proton spectroscopy in Alzheimer's dementia and amnestic mild cognitive impairment

RESUMO

Estudamos os achados da espectroscopia de prótons no córtex parietal-cíngulo posterior e das escalas MEEM, BRDS e FAST em pacientes com doença de Alzheimer – DA, comprometimento cognitivo amnéstico – CCA e controles normais – CN. Apenas as razões NAA/Cr e MI/NAA diferenciaram (p<0.002) os grupos DA e CN. Houve correlação significativa do NAA/Cr e do MI/NAA com o BRDS (pontuação total - PT; atividades cotidianas - AC) e FAST, e do MI/NAA com o MEEM. Houve acréscimo / We studied the findings of proton spectroscopy of the posterior parietal-cingulate cortex, and of MMSE, BRDS and FAST scales in subjects with Alzheimer disease – AD, amnestic mild cognitive impairment – MCI-A and normal controls – NC. Only NAA/Cr and MI/NAA differentiated (p<0.002) the AD and NC groups. Significant correlation was found between NAA/Cr and MI/NAA with BRDS (total score - TS; everyday activities - EA) and FAST scales, and between MI/NAA and MMSE. Specificity increased...