Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells
Biol. Res
; 39(1): 189-190, 2006. ilus
Artigo
em Inglês
| LILACS
| ID: lil-430712
Biblioteca responsável:
BR1.1
RESUMO
Recent evidence suggests that reactive oxygen species function as second messenger molecules in normal physiological processes. For example, activation of N-Methyl-D-Aspartate receptor results in the production of ROS, which appears to be critical for synaptic plasticity, one of the cellular mechanisms that underlie learning and memory. In this work, we studied the effect of iron in the activation of MAPK/ERK pathway and on Ca2+ signaling in neuronal PC12 cells. We found that iron-dependent generation of hydroxyl radicals is likely to modulate Ca2+ signaling through RyR calcium channel activation, which, in turn, activates the MAPK/ERK pathway. These findings underline the relevance of iron in normal neuronal function.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Espécies Reativas de Oxigênio
/
Canal de Liberação de Cálcio do Receptor de Rianodina
/
MAP Quinases Reguladas por Sinal Extracelular
/
Ferro
/
Neuroblastoma
Limite:
Animais
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2006
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
Instituição/País de afiliação:
Fondap Center for Molecular Studies of the Cell/CL
/
Universidad de Chile/CL