Frecuencia de los genes de fusión TEL/AML1 y BCR/ABL en pacientes pediátricos con leucemia linfoblástica aguda / Frequency of TEL/AML1 and BCR/ABL fusion genes in children with acute lymphoblastic leukemia
Rev. méd. Chile
; 134(11): 1367-1376, nov. 2006. ilus, tab
Artigo
em Espanhol
| LILACS
| ID: lil-439933
Biblioteca responsável:
BR1.1
ABSTRACT
Background:
t(12;21) (p12;q22) and t(9;22) (q34;q11) translocations have prognostic significance in acute lymphoblastic leukemia (ALL). The fusion genes TEL/AML1 y BCR/ABL, generated by these translocations, can be easily detected using molecular biology technique.Aim:
To study the frequency of TEL/AML1 y BCR/ABL fusion genes in children with ALL. Material andmethods:
Fifity six children with ALL (age range 1 month- 14 years) were studied, thirty eight from our Temuco Hospital and 18 from the Metropolitan Region. TEL/AML1 y BCR/ABL fusion genes were detected in bone marrow samples using a reverse transcriptase nested polymerase chain reaction (RT-PCR).Results:
TEL/AML 1 and BCR/ABL fusion gene transcripts were detected in 13 (23 percent) and 2 (4 percent) children, respectively. No differences in survival were observed between children with positive or negative transcripts for TEL/AML1 fusion gene. However, those positive for BCR/ABL fusion gene, had a significantly lower survival.Conclusions:
The frequency of TEL/AML1 and BCR/ABL fusion gene transcripts in these children with ALL is similar to that described by other authors.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Translocação Genética
/
Proteínas de Fusão Oncogênica
/
Proteínas de Fusão bcr-abl
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Limite:
Adolescente
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2006
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
Instituição/País de afiliação:
Clínica Alemana de Temuco/CL
/
Hospital Luis Calvo Mackenna/CL
/
Hospital del Salvador/CL
/
Universidad de La Frontera/CL