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Cytochrome P450 (CYP) and glutathione S-transferases (GST) polymorphisms (CYP1A1, CYP1B1, GSTM1, GSTP1 and GSTT1) and urinary levels of 1-hydroxypyrene in Turkish coke oven workers
Ada, Ahmet Oguz; Yilmazer, Meltem; Suzen, Sinan; Demiroglu, Canan; Demirbag, Ali Eba; Efe, Sibel; Alemdar, Yavuz; Burgaz, Sema; Iscan, Mumtaz.
Afiliação
  • Ada, Ahmet Oguz; Ankara University. Faculty of Pharmacy. Department of Toxicology. Tandogan. TR
  • Yilmazer, Meltem; Gazi University. Faculty of Pharmacy. Department of Toxicology. Etiler. TR
  • Suzen, Sinan; Ankara University. Faculty of Pharmacy. Department of Toxicology. Tandogan. TR
  • Demiroglu, Canan; Gazi University. Faculty of Pharmacy. Department of Toxicology. Etiler. TR
  • Demirbag, Ali Eba; Yuksek Ihtisas Hospital. Gastrointestinal Surgery Department. Sihhiye. TR
  • Efe, Sibel; Eregli Iron and Steel Works Co. Karadeniz Eregli. TR
  • Alemdar, Yavuz; Eregli Iron and Steel Works Co. Karadeniz Eregli. TR
  • Burgaz, Sema; Gazi University. Faculty of Pharmacy. Department of Toxicology. Etiler. TR
  • Iscan, Mumtaz; Ankara University. Faculty of Pharmacy. Department of Toxicology. Tandogan. TR
Genet. mol. biol ; 30(3): 511-519, 2007. tab
Artigo em Inglês | LILACS | ID: lil-460063
Biblioteca responsável: BR1.1
ABSTRACT
Genetic polymorphisms of xenobiotic metabolizing enzymes have been associated with cancer risk. We evaluated the influences of genetic polymorphisms of polycyclic aromatic hydrocarbon (PAH) metabolizing enzymes on urinary 1-hydroxypyrene (1-OHP) excretion in Turkish coke oven workers. Urinary 1-OHP was analyzed by HPLC after enzymatic hydrolysis. Lymphocyte DNA was used for PCR-based genotyping of cytochrome P450 (CYP) polymorphisms (CYP1A1 and CYP1B1) and glutathione S-transferases (GST) polymorphisms (GSTM1, GSTT1 and GSTP1). The mean urinary 1-OHP levels of coke oven workers were significantly higher than that of controls. No significant difference was detected in the mean urinary 1-OHP levels of smokers and non-smokers either for coke oven workers or controls. Genetic polymorphisms of the CYPs and GSTs studied had no significant influence on 1-OHP excretion in coke oven workers, but in the control group the urinary 1-OHP levels of individuals carrying the GSTT1- genotype were significantly higher than those of individuals carrying GSTT1+ genotype. The duration of occupational exposure and metabolic genotype for GSTT1 were the significant predictors of urinary 1-OHP levels. The control individuals carrying combined GSTM1-/GSTT1- genotypes also had significantly higher levels of urinary 1-OHP than those of individuals carrying GSTM1+/GSTTI+, GSTM1-/GSTT1+, and GSTM1+/GSTT1- genotypes. These results indicate that urinary 1-OHP is a sensitive indicator of recent human exposure to PAHs and that genetic polymorphism of GSTT1 may also to some extent reflect the interindividual variation in susceptibility to PAHs only at low PAH exposure.

Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Meta 3.9 Reduzir as mortes por produtos químicos y contaminação do ar, água e solo Problema de saúde: Exposições Ocupacionais Base de dados: LILACS Tipo de estudo: Estudo prognóstico Idioma: Inglês Revista: Genet. mol. biol Assunto da revista: Genética Ano de publicação: 2007 Tipo de documento: Artigo / Documento de projeto País de afiliação: Turquia Instituição/País de afiliação: Ankara University/TR / Eregli Iron and Steel Works Co/TR / Gazi University/TR / Yuksek Ihtisas Hospital/TR
Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Meta 3.9 Reduzir as mortes por produtos químicos y contaminação do ar, água e solo Problema de saúde: Exposições Ocupacionais Base de dados: LILACS Tipo de estudo: Estudo prognóstico Idioma: Inglês Revista: Genet. mol. biol Assunto da revista: Genética Ano de publicação: 2007 Tipo de documento: Artigo / Documento de projeto País de afiliação: Turquia Instituição/País de afiliação: Ankara University/TR / Eregli Iron and Steel Works Co/TR / Gazi University/TR / Yuksek Ihtisas Hospital/TR
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