Influencia del sistema nitridérgico en la respuesta contráctil a fenilefrina de anillos de vasos usados en revascularización coronaria / Modification of phenylephrine induced contraction of human vessel rings by L-arginine and L-arginine methyl ester
Rev. méd. Chile
; 135(10): 1231-1236, oct. 2007. graf
Artigo
em Espanhol
| LILACS
| ID: lil-470699
Biblioteca responsável:
BR1.1
ABSTRACT
Background:
Endothelial dysfunction is associated to a lower production of nitric oxide and a reduction of endothelium mediated vasodilation.Aim:
To study the effects of pharmacological agents that modify nitric oxide synthetase (NOS) activity on tension changes induced by phenylephrine in rings of internal mammary and radial arteries and saphenous vein. Material andmethods:
Vessel rings of 7 to 10 mm length were obtained from 32 patients subjected to coronary vascular surgery Fourteen samples of radial artery, 12 samples of internal mammary artery and 15 samples of saphenous vein were obtained. A maximal contraction was induced with KC1 and dose response curves for phenylephrine (FE) in the absence or presence of L-arginine and L-arginine methyl ester (L-NAME), were constructed.Results:
The tension induced by FE in internal mammary artery and saphenous vein reached a maximum, near 90 percent of 80 mM KCl-induced contraction, but in the radial artery, it reached a maximum of 63 percent (p <0.05). In all vessels, the dose response curves were significantly shifted to the right by L-arginine and to the íeft by L-NAME.Conclusions:
Pre-incubation of human rings with L-ARG or L-NAME, changed the response to FE induced contraction, which may be related to different degrees of endothelial nitric oxide production or NO sensitivity. The basal NO production in radial artery seems to be larger than the other vessels.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Fenilefrina
/
Arginina
/
Vasoconstritores
/
Óxido Nítrico Sintase
/
NG-Nitroarginina Metil Éster
/
Inibidores Enzimáticos
/
Músculo Liso Vascular
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2007
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
Instituição/País de afiliação:
Universidad de Chile/CL