High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile
Biol. Res
; 40(3): 365-372, 2007. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-481314
Biblioteca responsável:
BR1.1
ABSTRACT
The inactivation of tumour suppressor genes by aberrant methylation of promoter regions has been described as a frequent event in neoplasia development, including lung cancer. The p16 gene is a tumour suppressor gene involved in the regulation of cell cycle progression that has been reported to be inactivated by promoter methylation in lung carcinomas at variable frequencies around the world in a smoking habit dependent manner. The purpose of this study was to investigate the methylation status of the promoter region of the p16 gene in 74 non-small cell lung carcinomas from Chile. The frequency of p16 gene inactivation by promoter methylation was determined as 79.7 percent (59/74). When we considered histological type, we observed that p16 promoter methylation was significantly higher in squamous cell carcinomas (30/33, 91 percent) compared with adenocarcinomas (21/30, 70 percent) (p=0.029). In addition, no association between p16 promoter methylation and gender, age or smoking habit was found (p=0.202, 0.202 and 0.147 respectively). Our results suggest that p16 promoter hypermethylation is a very frequent event in non-small cell lung carcinomas from Chile and could be smoking habit-independent.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Fumar
/
Regiões Promotoras Genéticas
/
Carcinoma Pulmonar de Células não Pequenas
/
Metilação de DNA
/
Neoplasias Pulmonares
Tipo de estudo:
Estudo de etiologia
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Chile
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2007
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
/
Colômbia
/
Japão
Instituição/País de afiliação:
Instituto de Salud Pública de Chile/CL
/
Kagoshima University Graduate School of Medical and Dental Sciences/JP
/
Universidad Santo Tomás/CL