Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation
Braz. j. med. biol. res
; 42(2): 148-154, Feb. 2009. ilus
Artigo
em Inglês
| LILACS
| ID: lil-506882
Biblioteca responsável:
BR1.1
ABSTRACT
In this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-reactivation (memory reconsolidation) effects of icv infusions of hemicholinium, a central inhibitor of acetylcholine synthesis, of intraperitoneal administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, of intrahippocampal injections of an inhibitor of the transcription factor NF-κB, and the exposure of mice to a new learning situation on retention performance of an inhibitory avoidance response. All treatments impair long-term memory consolidation and retrieval-induced memory processes different from extinction, probably in accordance with the "reconsolidation hypothesis".
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Aprendizagem da Esquiva
/
NF-kappa B
/
NG-Nitroarginina Metil Éster
/
Memória
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2009
Tipo de documento:
Artigo
/
Congresso e conferência
País de afiliação:
Argentina
Instituição/País de afiliação:
Universidad de Buenos Aires/AR