Prognostic influence of clinical and pathological factors in medullary thyroid carcinoma: a study of 53 cases
Clinics
; 64(9): 849-856, 2009. tab
Artigo
em Inglês
| LILACS
| ID: lil-526324
Biblioteca responsável:
BR1.1
ABSTRACT
OBJECTIVES AND INTRODUCTION:
Medullary thyroid carcinoma, a neoplasia of intermediate prognosis and differentiation, does not always respond predictably to known treatments. This study aimed to correlate the clinical progression of surgically treated patients with clinical and pathological data.METHODS:
A total of 53 patients were followed for 75 months (mean average) in tertiary-care hospital. The clinical status of patients at the end of the study period was characterized to determine correlations with a range of disease aspects. A value of p < 0.05 was considered statistically significant.RESULTS:
Twenty-two patients (41.5 percent) were alive and disease-free at the end of the follow-up period; twenty-three patients (43.4 percent) had persistent disease; and eight patients (15.1 percent) had recurrent disease. Four patients (7.6 percent) died from medullary thyroid carcinoma with clinical and/or imaging evidence of neoplasia. The following aspects demonstrated statistically significant correlations with the final medical condition positive initial cervical examination (p = 0.002); neoplastic extensions to the thyroid capsule (p = 0.004) and adjacent tissues (p = 0.034); cervical lymph node metastases (p < 0.001); diameter of neoplasia (p = 0.018); TNM (tumor, node and metastasis) Stage (p = 0.001) and evidence of distant and/or cervical diseases in the absence of a cure (p = 0.011). Through logistic regression, the presence of cervical lymph node metastases was considered an independent variable (p < 0.001).CONCLUSIONS:
Clinical and pathological aspects of patients with surgically treated medullary thyroid carcinomas are predictors of disease progression. Specifically, even treated cervical lymph node metastases are significantly correlated with disease progression.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Doenças do Sistema Endócrino
/
Neoplasia da Tireoide
Base de dados:
LILACS
Assunto principal:
Neoplasias da Glândula Tireoide
/
Carcinoma Medular
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Brazilian Institute of Cancer/BR
/
Universidade de São Paulo/BR