Radioactive seed migration after prostate brachytherapy with Iodine-125 using loose seeds versus stranded seeds
Int. braz. j. urol
; 35(5): 573-580, Sept.-Oct. 2009. tab
Artigo
em Inglês
| LILACS
| ID: lil-532771
Biblioteca responsável:
BR1.1
ABSTRACT
Objectives:
To assess the incidence and clinical parameters that could influence migration of seeds in localized prostate cancer patients treated by stranded versus loose sources by Iodine-125 brachytherapy. Material andMethods:
100 patients were treated from January/1998 until December/2006. Age, PSA, clinical stage, Gleason, prostate volume, number of seeds, activity of radioactive seeds, and dosimetric parameters, such as V100, V150 and D90 were evaluated.Results:
Mean follow-up was 79 months (18 - 120. CI 95 percent 72 - 85). Overall, 6 of 100 patients experienced seed migration. Seed migration was found in 4/50 (8 percent) patients using loose seeds and in 2/50 (4 percent) treated by stranded seeds. Mean value dosimetric parameters for stranded seeds were greater than those for loose seeds (V100( percent) 88.7/82, D90(Gy) 149.2/140.3, D90( percent) 104.2/93.8, V150 ( percent) 53.8/47, respectively). No significant difference in migration of seeds was detected between loose and stranded seeds considering age (p = 0.33), PSA (p = 0.391), prostate volume (p = 0.397), activity of radioactive seeds (p = 0.109), number of seeds (p = 0.338), V100 (p = 0.332), although significant differences were measured in the values of D90( percent and Gy) (p = 0.022 and 0.011) and V150 (p = 0.023).Conclusions:
Seed migration after brachytherapy might occur and it does affect post-implant dosimetry.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Neoplasias da Próstata
/
Braquiterapia
/
Radioisótopos do Iodo
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Idoso
/
Idoso, 80 anos ou mais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Int. braz. j. urol
Assunto da revista:
Urologia
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Brazilian Institute of Oncology and Radioterapia Botafogo/BR
/
Federal University of Rio de Janeiro/BR