Antimycobacterial neolignans isolated from Aristolochia taliscana
Mem. Inst. Oswaldo Cruz
; 105(1): 45-51, Feb. 2010. tab, ilus
Artigo
em Inglês
| LILACS
| ID: lil-539295
Biblioteca responsável:
BR1.1
ABSTRACT
Tuberculosis (TB - Mycobacterium tuberculosis) is an ancient infectious disease that has appeared once again as a serious worldwide health problem and now comprises the second leading cause of death resulting from a single infection. The prevalence of multidrug resistance (MDR) TB is increasing and therapeutic options for treatment are not always accessible; in fact, some patients do not respond to the available drugs. Therefore, there is an urgent need to develop novel anti-TB agents. The aim of the present study was to screen extracts of Aristolochia taliscana, a plant used in traditional Mexican medicine to treat cough and snake bites, for antimycobacterial activity. The hexanic extract of A. taliscana was tested by microdilution alamar blue assay against Mycobacterium strains and bioguided fractionation led to the isolation of the neolignans licarin A, licarin B and eupomatenoid-7, all of which had antimycobacterial activity. Licarin A was the most active compound, with minimum inhibitory concentrations of 3.12-12.5 ìg/mL against the following M. tuberculosis strains H37Rv, four mono-resistant H37Rv variants and 12 clinical MDR isolates, as well as against five non-tuberculous mycobacteria (NTM) strains. In conclusion, licarin A represents a potentially active anti-TB agent to treat MDR M. tuberculosis and NTM strains.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
Problema de saúde:
Meta 3.8 Atingir a cobertura universal de saúde
/
Doenças Negligenciadas
/
Tuberculose
Base de dados:
LILACS
Assunto principal:
Extratos Vegetais
/
Lignanas
/
Aristolochia
/
Antibacterianos
/
Mycobacterium tuberculosis
Tipo de estudo:
Fatores de risco
Limite:
Humanos
País/Região como assunto:
México
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2010
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
México
Instituição/País de afiliação:
Centro Médico Nacional Siglo XXI/MX
/
Instituto Mexicano del Seguro Social/MX
/
Instituto Politécnico Nacional/MX
/
Unidad Investigación Médica en Farmacología de Productos Naturales/MX