Brain plasticity, signal transduction and epigenesis: a missing link revealed
ARBS annu. rev. biomed. sci
; ARBS annu. rev. biomed. sci;11(n.esp): T114-T122, 20090000. ilus
Article
em En
| LILACS
| ID: lil-560454
Biblioteca responsável:
BR33.1
ABSTRACT
It has been long thought that the brain reorganizes itself in response to environmental needs. Sensory experiences coded in action potentials are the mean by which information on the surroundings is introduced into neuronal networks. The information approaching the brain in the form of electrochemical codes must then be translated in biochemical, epigenetic and genetic ones. Only until recently we have begun understanding the underpinning of such informational transformations and how this process is expressed as neuronal plastic responses. Central for our comprehension of this matter is the finding that signals transduction cascades can modify gene expression by remodeling the chromatin through epigenetic mechanisms. Hence, chromatin remodeling seems to be the process by which experiences are imprinted.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Transdução de Sinais
/
Expressão Gênica
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Epigênese Genética
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Plasticidade Neuronal
Idioma:
En
Revista:
ARBS annu. rev. biomed. sci
Assunto da revista:
BIOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Brasil