Efectos de la glicina sobre los trastornos de conducción del nervio auditivo en pacientes diabéticos tipo 2 con otoneuropatía / Effects of glycine on auditory evoked potentials among diabetic patients with auditory pathway neuropathy
Rev. méd. Chile
; 138(10): 1246-1252, oct. 2010. graf, tab
Artigo
em Espanhol
| LILACS
| ID: lil-572935
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
Glycine inhibits the formation of advanced glycation end products that may cause central and peripheral neuronal damage, affecting also the auditory nerve.Aim:
To evaluate the effect of glycine on auditory nerve conduction and hearing level among patients with type 2 diabetes mellitus and auditory neuropathy. Material andMethods:
Twenty grams of oral glycine per day were administered during 6 months to 28 type 2 diabetic patients aged 58 ± 6 years, with auditory pathway neuropathy. Hearing tests and evoked otoacustic potentials were performed regularly. Fifteen diabetic patients aged 49 ± 8 years, without auditory nerve neuropathy did not receive glycine and were followed as a control group.Results:
Among patients receiving glycine, a significant improvement in left ear audiometry at 125, 250 and 500 Hz and right ear audiometry at 500 Hz, was observed. Waves I, III and V (p= 0.02) of evoked otoacustic potentials improved significantly in the left ear and wave I in the right ear. Among controls, waves V and III of evoked otoacoustic potentials had a significant impairment in the left ear.Conclusions:
There was an improvement in auditory evoked potentials in patients receiving glycine and an impairment in untreated control patients.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Vias Auditivas
/
Glicinérgicos
/
Neuropatias Diabéticas
/
Potenciais Evocados Auditivos
/
Glicina
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2010
Tipo de documento:
Artigo
País de afiliação:
México
Instituição/País de afiliação:
Delegación Oriente Estado de México/MX
/
Hospital General Regional 72/MX
/
Hospital Magdalena de las Salinas/MX