Impact of macrolide therapy on mortality of HIV-infected patients with community-acquired pneumonia in a tertiary teaching hospital
Braz. j. infect. dis
; 15(3): 262-267, May-June 2011. tab
Article
em En
| LILACS, SES-SP
| ID: lil-589959
Biblioteca responsável:
BR1.1
ABSTRACT
BACKGROUND:
Bacterial pneumonia is one of the main causes of morbidity and mortality in patients infected by the human immunodeficiency virus (HIV). The main objective of this study was to evaluate the effect of macrolide therapy in combination with a beta-lactam based empiric regimen for inpatients with community-acquired pneumonia and HIV.METHODS:
This is a retrospective cohort study of hospitalized patients. Adult patients who had received treatment with ceftriaxone or ceftriaxone plus clarithromycin were included.RESULTS:
76 patients met the inclusion criteria. Among baseline characteristics analyzed, only respiratory rate showed significant difference patients who had received clarithromycin were more likely to have a respiratory rate > 30/min than patients who received only ceftriaxone (64 percent versus 36 percent, p = 0.03). ICU admission was the only outcome that showed a significant difference, more frequent in the ceftriaxone plus clarithromycin group (45 percent versus 20 percent, p = 0.03).CONCLUSIONS:
This study does not support the addition of a macrolide to a beta-lactam based regimen in HIV-infected patients. This is probably related to the patients' immunodeficiency status, which impairs the immunomodulatory properties of the macrolides.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
/
SES-SP
Assunto principal:
Ceftriaxona
/
Claritromicina
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Infecções Oportunistas Relacionadas com a AIDS
/
Pneumonia Bacteriana
/
Antibacterianos
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Braz. j. infect. dis
Assunto da revista:
DOENCAS TRANSMISSIVEIS
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil