Advances in haploidentical stem cell transplantation
Rev. bras. hematol. hemoter
; 33(3): 237-241, June 2011.
Artigo
em Inglês
| LILACS
| ID: lil-596328
Biblioteca responsável:
BR408.1
ABSTRACT
Hematopoietic stem cell transplantation from haploidentical donors is an attractive method of transplantation due to the immediate donor availability, ease of stem cell procurement and the possibility to collect additional donor cells for cellular therapy, if needed. Historically, maintaining T-cells in the graft has been associated with very high rates of graft-versus-host disease, while T-cell depleted haploidentical transplantation has been limited by a higher incidence of graft rejection and delayed immune reconstitution post-transplant. Recent approaches attempt to maintain the T-cells in the graft while effectively preventing the development of graft-versus-host disease post-transplant. Selective depletion of alloreactive T-cells post-transplant using high-dose post-transplant cyclophosphamide is under investigation as a promising alternative in haploidentical transplantation. While engraftment has improved and graft-versus-host disease is controlled with this approach, future directions should focus on optimizing conditioning regimens and the prevention of disease relapse post-transplant.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Linfócitos T
/
Transplante de Medula Óssea
/
Transplante de Células-Tronco Hematopoéticas
/
Neoplasias Hematológicas
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. bras. hematol. hemoter
Assunto da revista:
Hematologia
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Estados Unidos
Instituição/País de afiliação:
The University of Texas M.D/US