Fertility in female survivors of Hodgkin's lymphoma
Rev. bras. hematol. hemoter
; 34(1): 48-53, 2012. tab
Artigo
em Inglês
| LILACS
| ID: lil-618303
Biblioteca responsável:
BR408.1
ABSTRACT
Currently, Hodgkin's lymphoma is one of the most curable types of cancer. Patients are often young and so the long-term morbidities of treatment have become of increasing concern. Among these, infertility is one of the most challenging consequences for patients in reproductive age. Premature ovarian failure in premenopausal women is a serious long-term sequel of the toxicity of chemotherapy. The main consequence of this syndrome is infertility, but women also present other symptoms related to estrogen deprivation. Different rates of impaired gonadal function are reported, depending on the patient's age, stage of disease, dose and intensity of chemotherapy and the use of radiation therapy. The most established strategy in female infertility is cryopreservation of embryos after in vitro fertilization. Additionally, the use of oral contraceptives or gonadotropinreleasing hormone analogs (GnRH-a) during treatment is under study. This review will provide a general overview of the main studies conducted to evaluate the infertility rate among female Hodgkin's lymphoma survivors and risk factors associated to treatment, different end-point definitions for evaluating fertility and also a brief description of the available strategies for fertility preservation.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Doença de Hodgkin
/
Sobreviventes
/
Fertilidade
Tipo de estudo:
Fatores de risco
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Rev. bras. hematol. hemoter
Assunto da revista:
Hematologia
Ano de publicação:
2012
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Itália
Instituição/País de afiliação:
L'Università di Modena e Reggio Emilia/IT
/
Ospedale Civile Santo Spirito/IT
/
Universidade Federal do Rio de Janeiro/BR