Pseudoneoplasia calificante del neuroeje / Calcifying pseudo tumor of CNS

ABSTRACT

Objetive to present a case of Calcifying Pseudoneoplasm of the Neuraxis (CPN). Description a 17 years old woman, with menstrual disorders and a mild hyperprolactinemia. She suffered from a chronic and moderate headache with normal clinic and neurologic examination. Brain non contrast CT showed a hyperdense mass in the right frontal lobe with dural relationship. In MRI it was a non enhancing T1 weighted hyperintense lesion, and a T2 weighted hypointense mass. The sellar region was clean. Intervention surgery with total excision was performed. The lesion was an off white an avascular tumor with meningeal adherence. It revealed a calcifiyed part and a soft mucoid portion. Histologically it presented amorphous, acellular chondromixoid matrix surrounded by pallisading spindle to polygonal epitheloid cells. These were tipically EMA positive and negative to GFAP. All these features led to the diagnosis of Calcifying Pseudoneoplasm of the Neuraxis. Conclusion: the CPN must be considered in the diagnosis and management of any patient with calcifyied, ossifyied mass of the Central Nervous System.