Induction of mitotic crossing-over in diploid strains of Aspergillus nidulansusing low-dose X-rays
Genet. mol. res. (Online)
; 7(2): 467-475, 2008.
Artigo
em Inglês
| LILACS
| ID: lil-640991
Biblioteca responsável:
BR26.1
ABSTRACT
As a contribution towards detecting the genetic effects of low doses of genotoxic physical agents, this paper deals with the consequences of low-dose X-rays in the Aspergillus nidulans genome. The irradiation doses studied were those commonly used in dental clinics (1-5 cGy). Even very low doses promoted increased mitotic crossing-over frequencies in diploid strains heterozygous for several genetic markers including the ones involved in DNA repair and recombination mechanisms. Genetic markers of several heterozygous strains were individually analyzed disclosing that some markers were especially sensitive to the treatments. These markers should be chosen as bio-indicators in the homozygotization index assay to better detect the recombinogenic/carcinogenic genomic effects of low-dose X-rays.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Aspergillus nidulans
/
Raios X
/
Troca Genética
/
Mitose
Idioma:
Inglês
Revista:
Genet. mol. res. (Online)
Assunto da revista:
Biologia Molecular
/
Genética
Ano de publicação:
2008
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
Centro Universitário Moura Lacerda/BR
/
Universidade de Franca/BR
/
Universidade de São Paulo/BR