Biochemical study of the effects of cilostazol in rats subjected to acute ischemia and reperfusion of hind limbs
Acta cir. bras
; 28(5): 361-366, May 2013. tab
Artigo
em Inglês
| LILACS
| ID: lil-674156
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To investigate whether cilostazol has a protective effect on acute ischemia and reperfusion of hind limbs of rats through study of biochemical variables in blood and urine.METHODS:
Forty six animals were randomized and divided into two groups. Group I received a solution of cilostazol (10 mg/Kg) and group II received saline solution 0.9% (SS) by orogastric tube after ligature of the abdominal aorta. After four hours of ischemia the animals were divided into four subgroups group IA (Cilostazol) two hours of reperfusion. Group IIA (SS) two hours of reperfusion. Group IB (Cilostazol) six hours of reperfusion. Group IIB (SS) six hours of reperfusion. After the reperfusion period, was held to collect urine and blood for biochemical measurements. The biochemical parameters studied were urea, creatinine, sodium, potassium and myoglobin in blood and urea, creatinine, myoglobin in urine.RESULTS:
There was no statistically significant difference between groups.CONCLUSION:
Cilostazol had no protective effect on ischemic acute reperfusion of hind limbs of rats in this model.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Tetrazóis
/
Inibidores da Agregação Plaquetária
/
Traumatismo por Reperfusão
/
Membro Posterior
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2013
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
UMC/BR