Evaluation of nerve regeneration in diabetic rats
Acta cir. bras
; 28(7): 509-517, July 2013. ilus, graf, tab
Artigo
em Inglês
| LILACS
| ID: lil-679083
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To compare sciatic nerve regeneration between non-diabetic (control) and streptozotocin-induced diabetic Wistar rats.METHODS:
Four subgroups were evaluated. CN Non-diabetic rats submitted to neurorrhaphy (n=9); DN Diabetic rats submitted to neurorrhaphy (n=9); CG Non-diabetic rats submitted to nerve grafting (n=10); DG Diabetic rats submitted to nerve grafting (n=9). The nerve regeneration was evaluated by walking track analysis (sciatic functional index), electrophysiological test, histomorphometric analysis and triceps surae muscle weight.RESULTS:
At 60 days post-surgery, functional recovery of DN was similar to that of the non-diabetic rats (CN, CG), but DG didn't achieve the same. Evoked potential amplitudes showed no statistically significant differences among subgroups. Triceps surae muscle was heavier in CN. No statistically significant differences were observed between the control and diabetes subgroups with respect to histomorphometric analysis.CONCLUSION:
After 60 days, DN had a functionally similar recovery to that of the control animals, whereas nerve grafting in diabetic rats didn't allow the same. The muscle atrophy was lower in CN. In the rest of evaluations, as electrophysiological and histomorphometric, diabetic rats were not different from control ones.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Nervo Isquiático
/
Diabetes Mellitus Experimental
/
Regeneração Nervosa
Tipo de estudo:
Estudo de avaliação
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2013
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
USP/BR