Does acute alcohol intoxication interfere with colonic anastomosis wound healing?: a rat model of nondestructive colon trauma
Acta cir. bras
; 28(10): 703-707, Oct. 2013. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-687743
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To evaluate the effects of acute alcohol intoxication on healing of colonic anastomosis.METHODS:
Thirty-six rats were allocated into two groups. Animals in the alcohol (A) were given 2 mL of ethanol diluted in 0.9% saline solution to a concentration of 40% by gavage immediately before anesthesia, whereas control (C) animals received 2 mL of 0.9% saline solution via the same route. A colonic anastomosis was then performed in all animals. On postoperative days 1, 3, and 7, anastomotic breaking strength was assessed and histopathological examination was performed. Change in body weight and mortality were also evaluated.RESULTS:
The median of anastomotic tensile strength on the postoperative day 1 was 0.09 Newtons for group A and 0.13 for group C. (p>0.05). The median of anastomotic tensile strength on the postoperative day 3 was 0.13 Newtons for group A and 0.17 for group C. (p>0.05). The median of anastomotic tensile strength on the postoperative day 7 was 0.30 Newtons for group A and 0.35 for group C. (p>0.05). There was no significant difference between the groups A and C, in the first, third or seventh POD (p>0.05), in any of the analyzed parameters. There were no statistical differences between groups in the weight. Three animals died, all from the group A.CONCLUSION:
Acute alcohol intoxication did not interfere with wound healing of colonic anastomoses, although it caused early postoperative mortality.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Resistência à Tração
/
Cicatrização
/
Colo
/
Intoxicação Alcoólica
Tipo de estudo:
Ensaio clínico controlado
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2013
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Brasilia University/BR