Efecto de drogas antifungicas sobre factores de virulencia de especies candida / Effect of antifungal drugs on virulence factors of Candida species

RESUMEN

La candidiasis bucal es la micosis más frecuente en el humano y es causada principalmente por C. Albicans. Sin embargo, otras especies están aumentando su frecuencia como agentes causantes de dicha enfermedad. La capacidad de Candida para persistir en el epitelio oral está relacionada con su virulencia, a la cual contribuyen diferentes factores como la capacidad de adhesión, la hidrofobicidad de la superficie celular, la producción y secreciçón de enzimas hidrolíticas y el dimorfismo levadura-hifa. La pared celular del hongo está involucrada en todos estos factores por lo que su composición y estructura juegan un papel importante en la patogénesis de la candidiasis. Summary: Oral candiodosis is the most common fungal infection in humans which is mainly caused by C. albicans. However, other species are increasing their frequency as etiological agents of this pathology. The ability of candida to persiste in the oral epithelium is associated with its virulence which is formed by the contribution of different factors like cell adhesion, cell surface hydrophobicity, synthesis and secretion of hydrolytic enzymes, and yeast-hyphae dimorphism. The cell wall of candida is involved in all these virulence factors; that are why its composition and structure might play an important role in the pathogenesis

ABSTRACT

Oral candiodosis is the most common fungal infection in humans which is mainly caused by C. albicans. However, other species are increasing their frequency as etiological agents of this pathology. The ability of candida to persist in the oral epithelium is associated with its virulence which is formed by the contribution of epithelium is associated with its virulence which is formed by the contribution of different factors like cell adhesion, cell surface hyphae dimorphism