Estimadores de mezcla amerindia basados en métodos serológicos y moleculares / Amerindian admixture estimation based on serological and molecular methods
Rev. méd. Chile
; 143(4): 439-443, abr. 2015. tab
Artigo
em Espanhol
| LILACS
| ID: lil-747549
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
Amerindian admixture is an important parameter to consider in epidemiological studies in American countries, to make a proper selection of cases and controls.Aim:
To compare Amerindian admixture estimates obtained using ABO*A and ABO*O blood group alleles and ancestral identity markers (AIMs) in the mixed Chilean population. Subjects andMethods:
Amerindian admixture rates were determined in 720 Chilean volunteers residing in Arica and born in the 15 regions of the country, using ABO*O and ABO*A alleles and 40 AIMs selected from more than 500,000 single nucleotide polymorphisms (SNP´s).Results:
Mean admixture estimates obtained using ABO*O and ABO*A alleles and AIM s were 35, 47% and 48% respectively. There was concordance in estimates, with the exception of the admixture based on ABO*O allele and AIMs.Conclusions:
In Chile, Amerindian admixture estimates obtained using ABO*A could be used as an alternative to AIMs in justified cases provided the sample size is reasonably large.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Sistema ABO de Grupos Sanguíneos
/
Indígenas Sul-Americanos
/
População Branca
Limite:
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Chile
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2015
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Centro de Investigaciones del Hombre en el Desierto/CL